CAROMICS

New and hi-tech strategies for the study of kidney cancer. Use of “OMICS” and systems biology approaches for the development of new biomarkers

ABSTRACT

In this project we address the problem of explaining the mechanisms that cause the normal adult renal stem cell to become neoplastic by adopting a systematic biology approach, i.e. trough 1) the implementation of mathematical methods for the integration and the data mining of biological data starting from the level of the genome, through the transcriptome and the proteome, up to and including the metabolome; 2) the analysis of interaction patterns at the different molecular scales.

The first step of the analysis is aimed at the identification of the main molecules involved, of the most relevant differently deregulated biological processes, cellular functions and pathways in the adult cancer stem cell (CST) in respect to the normal ones (CS). This will be done by analyzing the multidimensional data coming from the high-throughput platforms of genomics, transcriptomics, proteomics and metabolomics. The second step addresses the problem of estimating the conditional dependences between molecular entities at different scales in order to characterize the CST cells in terms of gene regulation, protein-protein or metabolite-metabolite interactions.

PRINCIPAL INVESTIGATOR
NICOLA ANCONA

   TYPE AND DATE
   NATIONAL PROJECT
   STARTING DATE – Jan 1, 2011
   ENDING DATE – Dec 31, 2015

COST
TOTAL COST €: 1.770.000,00
TOTAL FUNDING € 1.545.000,00

CNR ISSIA
COST € 219.700,00
FUNDING € 179.290,00

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SOURCE OF FOUNDING

PARTNERSHIP

University of Bari, Italy
National Research Council, Institute of Intelligent Systems for Automation, Italy

University of Foggia, Italy
University of Salento, Italy