Chronic rejection in kidney transplantation: identification of new diagnostic targets

ABSTRACT

This project addresses the problem of identifying new diagnostic biomarkers associated to chronic rejection in patients subjected to kidney transplantation. In particular the research activity of our unit is focused on the reverse-engineering of gene regulatory networks and inference of co-expression networks in diseased tissues. The aim of the study is to investigate direct and undirect interactions and to reveal alterations emerging in diseased gene networks with respect to healthy controls.

 

computer-based image. (courtesy of Matthias Kretzler, Princeton and Michigan University)

PRINCIPAL INVESTIGATOR
NICOLA ANCONA

   TYPE AND DATE
   National Project – Oriented Research
   STARTING DATE – Dec 1, 2011
   ENDING DATE – Nov 30, 2014

COST
TOTAL COST €: 361.058,00
TOTAL FUNDING € 361.058,00

CNR ISSIA
COST € 55.000,00
FUNDING € 55.000,00

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SOURCE OF FOUNDING

PARTNERSHIP

Dipartimento di Scienze Biomediche Universita’ degli Studi di Foggia
Dipartimento dell’Emergenza e dei Trapianti di Organo, Universita’ degli Studi di Bari
Dipartimento di Medicina Interna, Universita’ degli Studi di Torino
Istituto di Studi sui Sistemi Intelligenti per l’Automazione, CNR